Rose bengal (4,5,6,7-tetrachloro-2',4',5',7'-tetraiodofluorescein) is a stain. Rose bengal belongs to the class of organic compounds called xanthenes.[1] Its sodium salt is commonly used in eye drops to stain damaged conjunctival and corneal cells and thereby identify damage to the eye. The stain is also used in the preparation of Foraminifera for microscopic analysis, allowing the distinction between forms that were alive or dead at the time of collection.
A form of rose bengal is also being studied as a treatment for certain cancers and skin conditions. The cancer formulation of the drug, known as PV-10, is currently undergoing clinical trials for melanoma,breast cancer. and neuroendocrine tumors. The company also has formulated a drug based on rose bengal for the treatment of eczema and psoriasis; this drug, PV-10, is currently in clinical trials as well.
(BR)
pH(0.5 g/L,25ºC) 6.0~8.0
Solubility(in water)
Residue ignition ≤18.0%
90%:
Appearance
Infrared spectrometry
Dye-content >90 %
Loss on drying <5 % (105°C)
λ max 545 - 550 nm (in water)
Absorpt. Ratio P-15/P+15 1.21 - 1.95
95%:
Appearance
Infrared spectrometry Conforms
Purity ≥95.0% (HPLC)
λ 546 - 550 nm
c = 0.004g/L H2O + 1ml 1% Na2CO3
Extinction Coefficient ≥98000
λ 513 - 517 nm
Extinction Coefficient ≥32000
λ 350 - 354 nm
Extinction Coefficient ≥3000
λ 311 - 315 nm
Extinction Coefficient ≥12000
λ 262 - 266 nm
Extinction Coefficient ≥32000